The NUP54 Polyclonal Antibody (CAB15454) is a vital tool for researchers studying nucleoporin 54 (NUP54), a key protein involved in nuclear pore complex assembly and function. This antibody, developed through rabbit immunization, exhibits high reactivity with human samples and has been validated for use in Western blot applications.NUP54 plays a crucial role in nucleocytoplasmic transport, regulating the passage of molecules between the nucleus and cytoplasm. Dysregulation of NUP54 has been linked to various diseases, including cancer and neurological disorders, making it an important target for research.
By binding specifically to the NUP54 protein, this antibody enables precise detection and analysis in a variety of cell types, offering valuable insights into nuclear transport mechanisms.Understanding the functions and regulatory mechanisms of NUP54 can provide valuable insights into cellular processes and disease pathology. The NUP54 Polyclonal Antibody is a valuable tool for researchers investigating the roles of NUP54 in health and disease, with potential implications for therapeutic development and disease management.
Product Name:
NUP54 Rabbit Polyclonal Antibody
SKU:
CAB15454
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human NUP54 (NP_059122.2).
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
53371
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NUP54 Rabbit pAb (CAB15454) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
