The NRXN1 Polyclonal Antibody (PACO05753) is a valuable tool for researchers studying neurexin-1 (NRXN1), a cell adhesion molecule involved in synaptic function and neurodevelopment. This antibody is produced in rabbits and exhibits high specificity and sensitivity for detecting NRXN1 in human samples. Validated for use in Western blot applications, the antibody binds specifically to the NRXN1 protein, allowing for precise detection and analysis in a variety of cell types.Neurexin-1 is a key player in synaptic transmission and has been implicated in neurodevelopmental disorders such as autism spectrum disorders and schizophrenia.
By targeting NRXN1, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets. The NRXN1 Polyclonal Antibody is an essential tool for studies in neuroscience, developmental biology, and neurology, providing crucial information for advancing our understanding of brain function and related disorders.
Antibody Name:
NRXN1 Antibody (PACO05753)
Antibody SKU:
PACO05753
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human Neurexin I.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
NRXN1; KIAA0578; Neurexin-1-α; Neurexin I-α
UniProt Protein Function:
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis.
NCBI Summary:
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
