The NR3C1 Polyclonal Antibody (CAB13667) is a valuable tool for researchers studying the NR3C1 protein, also known as the glucocorticoid receptor. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to NR3C1, this antibody enables detection and analysis of the protein in various cell types, allowing for deeper insights into its role in mediating glucocorticoid signaling pathways.The glucocorticoid receptor plays a crucial role in modulating immune and inflammatory responses, making it a key target for studies in immunology, endocrinology, and cancer research.
Dysregulation of NR3C1 has been implicated in various diseases, including autoimmune disorders, metabolic disorders, and certain types of cancer. By using the NR3C1 Polyclonal Antibody, researchers can further elucidate the mechanisms by which NR3C1 influences disease pathogenesis and identify potential therapeutic interventions targeting this pathway.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Purification Method:
Affinity purification
Gene ID:
2908
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using Glucocorticoid Receptor antibody (CAB13667) at dilution of 1:100. Blue: DAPI for nuclear staining.
