The NPPB Polyclonal Antibody (CAB2179) is a valuable tool for researchers studying the role of Natriuretic Peptide B (NPPB) in cardiovascular health and disease. This antibody, produced in rabbits, is highly specific and reactive with human samples, allowing for accurate detection and analysis in Western blot applications. By targeting the NPPB protein, this antibody enables researchers to explore the function and regulation of NPPB in various cell types, providing insights into its potential as a biomarker or therapeutic target in cardiovascular conditions.NPPB, also known as B-type natriuretic peptide (BNP), is a hormone secreted by the heart in response to increased cardiac wall stress, serving as a key player in regulating blood pressure and fluid balance.
Elevated levels of NPPB are associated with heart failure, making it an important marker for diagnosis and prognosis in cardiovascular diseases. By studying the expression and activity of NPPB, researchers can gain a better understanding of its role in cardiovascular pathophysiology and identify novel therapeutic strategies for managing cardiac disorders.
Product Name:
BNP Rabbit Polyclonal Antibody
SKU:
CAB2179
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 35-134 of human BNP (NP_002512.1).
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
Purification Method:
Affinity purification
Gene ID:
4879
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using BNP Rabbit pAb (CAB2179) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
