The NNT Polyclonal Antibody (CAB4561) is a valuable tool for researchers studying NNT, a crucial enzyme involved in cellular energy regulation and oxidative stress response. This antibody, produced using rabbit immunization, demonstrates high specificity towards human samples and is suitable for use in Western blot applications. By targeting the NNT protein, this antibody enables precise detection and analysis in various cell types, making it a valuable asset in studies of metabolism, mitochondrial function, and oxidative stress pathways.NNT, also known as nicotinamide nucleotide transhydrogenase, plays a vital role in maintaining cellular redox balance and protecting against oxidative damage.
Dysregulation of NNT has been implicated in a variety of diseases, including metabolic disorders, neurodegenerative conditions, and cancer. Therefore, investigating the function and regulation of NNT is essential for understanding the pathophysiology of these diseases and developing targeted therapeutic interventions.Overall, the NNT Polyclonal Antibody (CAB4561) offers researchers a reliable tool for exploring the intricate mechanisms of cellular metabolism and oxidative stress, with potential implications for the development of novel treatment strategies for a range of human illnesses.
Product Name:
NNT Rabbit Polyclonal Antibody
SKU:
CAB4561
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 881-1086 of human NNT (NP_036475.3).
This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification.
Purification Method:
Affinity purification
Gene ID:
23530
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NNT Rabbit pAb (CAB4561) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
