The NME1/NM23A Polyclonal Antibody offered by AssayGenie is a powerful tool for studying NME1/NM23A, a tumor metastasis suppressor gene with roles in cell differentiation, development, and metastasis. This antibody is produced in rabbits and is highly specific for human samples, making it an ideal choice for Western blot applications. By detecting and binding to the NME1/NM23A protein, researchers can gain insights into its function and potential therapeutic applications in cancer and other diseases.NME1/NM23A is a multifunctional protein that plays a crucial role in tumor suppression, cell motility, and metastasis inhibition. Its dysregulation has been implicated in various cancers, making it a promising target for cancer research and drug development.
By studying the expression and activity of NME1/NM23A using this antibody, researchers can uncover new pathways and mechanisms involved in cancer progression, as well as potential therapeutic interventions targeting this important protein.Overall, the NME1/NM23A Polyclonal Antibody from AssayGenie is a valuable tool for scientists studying cancer biology, metastasis, and cell signaling pathways. Its high specificity and sensitivity make it an excellent choice for investigating the role of NME1/NM23A in disease progression and identifying new therapeutic targets for cancer treatment.
Product Name:
NME1/NM23A Polyclonal Antibody
SKU:
CAB21512
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 10-110 of human NME1/NM23A (NP_000260.1).
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Purification Method:
Affinity purification
Gene ID:
4830
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NME1/NM23A Rabbit pAb (CAB21512).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
