Based on the information from the URL provided, we have the NHLH1/NHLH2 Antibody (PAC021822), which is a highly specific antibody designed for research applications involving the NHLH1 and NHLH2 proteins. The antibody is raised in rabbits and is validated for use in techniques such as Western blot and immunohistochemistry.NHLH1 and NHLH2 are transcription factors that play crucial roles in gene regulation and cellular differentiation. They have been implicated in various biological processes, including development, cell cycle control, and neurogenesis. The NHLH1/NHLH2 Antibody binds specifically to these proteins, allowing for their detection and analysis in different cell types and tissues.
Research on NHLH1 and NHLH2 is essential for understanding their functions in normal cellular processes and disease pathogenesis. Aberrant expression or dysfunction of these transcription factors has been linked to various disorders, including cancer, neurological diseases, and developmental abnormalities. Therefore, the NHLH1/NHLH2 Antibody serves as a valuable tool for examining the roles of NHLH1 and NHLH2 in these conditions and may aid in the development of potential diagnostic or therapeutic strategies.
Antibody Name:
NHLH1/NHLH2 Antibody (PACO21822)
Antibody SKU:
PACO21822
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human HEN1/2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen The MGC Project Team, Genome Res. 14:2121-2127(2004).
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using HEN1/2 antibody.
NHLH1: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: nucleus
Biological Process: central nervous system development; positive regulation of transcription from RNA polymerase II promoter
NCBI Summary:
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]
