The NeuroD2 Polyclonal Antibody (PAC060961) is a valuable tool for researchers studying the NeuroD2 protein, which plays a crucial role in the development and function of the nervous system. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot analysis.NeuroD2 is a transcription factor that is essential for neuronal differentiation and survival. It is involved in regulating the expression of genes that are critical for proper neuronal function, making it a key player in neurodevelopmental processes.
Dysregulation of NeuroD2 has been implicated in various neurological disorders, such as epilepsy and schizophrenia, highlighting its importance in understanding brain function.By utilizing the NeuroD2 Polyclonal Antibody, researchers can effectively detect and analyze NeuroD2 expression in different cell types, providing insights into its role in neural development and function. This antibody is an essential tool for studies in neuroscience and neurology, offering valuable information that can contribute to the development of novel therapeutic approaches for neurological diseases.
Antibody Name:
NEUROD2 Antibody (PACO60961)
Antibody SKU:
PACO60961
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Neurogenic differentiation factor 2 protein (254-339AA)
Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).
Synonyms:
Neurogenic differentiation factor 2 (NeuroD2) (Class A basic helix-loop-helix protein 1) (bHLHa1) (NeuroD-related factor) (NDRF), NEUROD2, BHLHA1 NDRF
UniProt Protein Function:
Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.
NCBI Summary:
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]
