The Neurexin-1 Polyclonal Antibody (CAB10066) is a valuable tool for researchers studying Neurexin-1, a cell adhesion molecule involved in synaptic plasticity and neurotransmission. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By binding specifically to Neurexin-1 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for studies in neuroscience and neurobiology.Neurexin-1 is a key player in synaptic communication and function, playing a crucial role in maintaining proper neural connections and signal transmission in the brain.
Dysregulation of Neurexin-1 has been implicated in various neurological disorders, including autism spectrum disorders, schizophrenia, and Alzheimer's disease. By investigating the function and expression of Neurexin-1 using this antibody, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets for intervention.
Product Name:
NRXN1 Rabbit Polyclonal Antibody
SKU:
CAB10066
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 31-310 of human NRXN1 (NP_001129131.1).
Cell junction, Cell membrane, Single-pass type I membrane protein, synapse.
Calculated MW:
15kDa/46kDa/161kDa/164kDa/169kDa
Observed MW:
162kDa
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.
Purification Method:
Affinity purification
Gene ID:
9378
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NRXN1 antibody (CAB10066) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
