NRXN1 Rabbit Polyclonal Antibody (CAB10066)
- SKU:
- CAB10066
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | NRXN1 Rabbit Polyclonal Antibody |
SKU: | CAB10066 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-310 of human NRXN1 (NP_001129131.1). |
Sequence: | LEFP GAEG QWTR FPKW NACC ESEM SFQL KTRS ARGL VLYF DDEG FCDF LELI LTRG GRLQ LSFS IFCA EPAT LLAD TPVN DGAW HSVR IRRQ FRNT TLFI DQVE AKWV EVKS KRRD MTVF SGLF VGGL PPEL RAAA LKLT LASV RERE PFKG WIRD VRVN SSQV LPVD SGEV KLDD EPPN SGGG SPCE AGEE GEGG VCLN GGVC SVVD DQAV CDCS RTGF RGKD CSQE IKFG LQCV LPVL LHDN DQGK YCCI NTAK PLTE KDNN VEGL AHLM MGDQ GKSK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PTHSL2; SCZD17; Hs.22998; NRXN1 |
Positive Sample: | SH-SY5Y,HepG2,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Single-pass type I membrane protein, synapse. |
Calculated MW: | 15kDa/46kDa/161kDa/164kDa/169kDa |
Observed MW: | 162kDa |
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.
Purification Method: | Affinity purification |
Gene ID: | 9378 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |