The NETO2 Polyclonal Antibody (PAC037970) is a valuable tool for researchers studying NETO2, a protein involved in synaptic transmission and plasticity in the brain. This antibody, developed in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to NETO2, this antibody enables precise detection and analysis of the protein in various cell types, making it an essential reagent for neuroscience and neurobiology research.NETO2, also known as neuropilin and tolloid-like 2, is a crucial regulator of excitatory neurotransmission and synaptic plasticity, playing a key role in the development and function of neural circuits. Dysregulation of NETO2 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorders.
Therefore, investigating the function and expression of NETO2 is essential for gaining insights into the pathophysiology of these conditions and potentially identifying therapeutic targets for novel treatments.In conclusion, the NETO2 Polyclonal Antibody is a reliable tool for researchers interested in exploring the role of NETO2 in neuronal communication and synaptic function. Its high specificity and sensitivity make it an invaluable asset for studies aimed at understanding the molecular mechanisms underlying brain disorders and developing targeted interventions for neurological diseases.
Western blot. All lanes: NETO2 antibody at 4µg/ml. Lane 1: U251 whole cell lysate. Lane 2: MDA-MB-231 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 60, 23, 59 kDa. Observed band size: 70 kDa.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO37970 at dilution of 1:100.
Background:
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.
Synonyms:
Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2), NETO2, BTCL2
UniProt Protein Function:
NETO2: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 16q11Cellular Component: kainate selective glutamate receptor complex; postsynaptic densityMolecular Function: ionotropic glutamate receptor binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
