The NEK8 Polyclonal Antibody (CAB0984) is a valuable tool for research involving NEK8, a protein kinase that plays a crucial role in cell cycle regulation and cilia formation. The antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blotting and immunohistochemistry applications.NEK8 is known for its involvement in various cellular processes, including cell division, DNA damage response, and ciliary function. Dysfunction of NEK8 has been linked to ciliopathies, a group of genetic disorders characterized by abnormal cilia structure and function.
By targeting NEK8 with this polyclonal antibody, researchers can investigate its role in these processes and potentially uncover new insights into ciliopathies and other related diseases.Overall, the NEK8 Polyclonal Antibody (CAB0984) offers a reliable and specific tool for studying the function and regulation of NEK8 in various biological contexts, making it a valuable asset for researchers in the fields of cell biology, genetics, and ciliopathy research.
Product Name:
NEK8 Rabbit Polyclonal Antibody
SKU:
CAB0984
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-390 of human NEK8 (NP_835464.1).
This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.
Purification Method:
Affinity purification
Gene ID:
284086
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using NEK8 Rabbit pAb (CAB0984) at 1:500 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 180s.
