UniProt Protein Function: | NAPEPLD: Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors. Belongs to the NAPE-PLD family.Protein type: EC 3.1.4.54; PhospholipaseChromosomal Location of Human Ortholog: 7q22.1Cellular Component: cytoplasmMolecular Function: zinc ion bindingBiological Process: phototransduction, visible light; phospholipid catabolic process; retinoid metabolic process |
UniProt Protein Details: | |
NCBI Summary: | NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008] |
UniProt Code: | Q6IQ20 |
NCBI GenInfo Identifier: | 170932481 |
NCBI Gene ID: | 222236 |
NCBI Accession: | NP_945341.3 |
UniProt Secondary Accession: | Q6IQ20,Q5CZ87, Q769K1 |
UniProt Related Accession: | Q6IQ20 |
Molecular Weight: | 45,596 Da |
NCBI Full Name: | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D |
NCBI Synonym Full Names: | N-acyl phosphatidylethanolamine phospholipase D |
NCBI Official Symbol: | NAPEPLDÂ Â |
NCBI Official Synonym Symbols: | FMP30; NAPE-PLDÂ Â |
NCBI Protein Information: | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D |
UniProt Protein Name: | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D |
UniProt Synonym Protein Names: | |
Protein Family: | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase |
UniProt Gene Name: | NAPEPLDÂ Â |
UniProt Entry Name: | NAPEP_HUMAN |