The MUTL Antibody (PAC050454) is a highly specific and sensitive tool for researchers studying MUTL, a key protein involved in DNA mismatch repair. This polyclonal antibody is raised in rabbits and has been validated for use in various applications, including Western blot and immunofluorescence. MUTL is essential for maintaining genomic stability by correcting errors that arise during DNA replication, making it a crucial player in preventing mutations and promoting DNA integrity.
Dysfunction of MUTL has been linked to various genetic disorders and cancer, highlighting its importance in maintaining cellular health.By using the MUTL Antibody, researchers can accurately detect and analyze MUTL protein levels in different cell types and experimental conditions. This antibody is a valuable tool for studying DNA repair mechanisms, cancer biology, and genetic diseases, ultimately contributing to the advancement of medical research and therapeutics.
Antibody Name:
mutL Antibody (PACO50454)
Antibody SKU:
PACO50454
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli DNA mismatch repair protein MutL protein (1-615AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: mutL antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. predicted band size: 68 kDa. observed band size: 68 kDa..
Background:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA.
Synonyms:
DNA mismatch repair protein MutL, mutL
UniProt Protein Function:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA.
UniProt Protein Details:
NCBI Summary:
MutL DNA-binding is required for methyl-directed mismatch repair (Robertson, 2006). [More information is available at EcoGene: EG11281]. MutL is one of the components of the MutHLS complex. [More information is available at EcoCyc: EG11281].
