MTMR7 Antibody (PACO42582)
- SKU:
- PACO42582
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
MTMR7 Antibody (PACO42582)
The MTMR7 Polyclonal Antibody (PAC042582) is a crucial tool for researchers studying MTMR7, a member of the myotubularin-related protein family that is involved in regulating cell growth, survival, and differentiation. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.MTMR7 is known to have phosphatase activity and plays a role in signaling pathways related to cell proliferation and survival.
Its dysregulation has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.By detecting and analyzing the expression of MTMR7 in different cell types, researchers can gain insights into its functions and potential implications in disease pathology. The MTMR7 Polyclonal Antibody is a valuable tool for advancing research in molecular biology, cell biology, and biomedicine.
| Antibody Name: | MTMR7 Antibody (PACO42582) |
| Antibody SKU: | PACO42582 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Myotubularin-related protein 7 protein (1-660AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: MTMR7 antibody at 2µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 76, 65 kDa. Observed band size: 76 kDa. |
| Background: | Phosphatase that acts on lipids with a phosphoinositol headgroup. |
| Synonyms: | Myotubularin-related protein 7 (EC 3.1.3.-), MTMR7 |
| UniProt Protein Function: | MTMR7: a protein of the myotubularin family. Myotubularins are a family of unique protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as physiological substrates. Myotubularins specifically dephosphorylate phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. PI(3)P and PI(3,5)P2 regulate membrane trafficking events through the recruitment of effector proteins containing the lipid-binding domains FYVE, PH, and ENTH. MTMR5, -9, -10, -11, -12, -13 are catalytically inactive lipid phosphatases but may mediate important protein-protein interactions. Expressed at high levels in the brain. Two alternatively spliced human isoforms have been described.Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.-; Phosphatase, lipidChromosomal Location of Human Ortholog: 8p22Cellular Component: membrane; cytosolMolecular Function: protein tyrosine phosphatase activityBiological Process: phospholipid metabolic process; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q9Y216 |
| NCBI GenInfo Identifier: | 225543474 |
| NCBI Gene ID: | 9108 |
| NCBI Accession: | BC130579 |
| UniProt Secondary Accession: | Q9Y216,Q68DX4, A1L4K9, B4DG87 |
| UniProt Related Accession: | Q9Y216 |
| Molecular Weight: | |
| NCBI Full Name: | myotubularin-related protein 7 |
| NCBI Synonym Full Names: | myotubularin related protein 7 |
| NCBI Official Symbol: | MTMR7Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | myotubularin-related protein 7 |
| UniProt Protein Name: | Myotubularin-related protein 7 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Myotubularin-related protein |
| UniProt Gene Name: | MTMR7Â Â |
| UniProt Entry Name: | MTMR7_HUMAN |
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