The MRPL50 Antibody (PAC01103) is a powerful tool for research involving the mitochondrial ribosomal protein L50 (MRPL50), a key player in mitochondrial protein synthesis. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting.MRPL50 is essential for the assembly of the large subunit of the mitochondrial ribosome, making it crucial for proper mitochondrial function and cellular respiration. Dysregulation of MRPL50 has been linked to mitochondrial dysfunction and various metabolic disorders, highlighting its importance in human health.
By targeting the MRPL50 protein, this antibody enables researchers to study the role of MRPL50 in mitochondrial protein synthesis and its impact on cellular metabolism. It is a valuable tool for investigating mitochondrial diseases, aging-related disorders, and metabolic conditions, providing insights into potential therapeutic strategies targeting MRPL50 and mitochondrial function.
Antibody Name:
MRPL50 Antibody
Antibody SKU:
PACO01103
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human MRP-L50.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL50; 39S ribosomal protein L50; mitochondrial; L50mt; MRP-L50
UniProt Protein Function:
MRPL50: 2 isoforms of the human protein are produced by alternative splicingChromosomal Location of Human Ortholog: 9q31.1Cellular Component: mitochondrial inner membrane
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]
