| UniProt Protein Function: | MRPL49: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]Protein type: Ribosomal; Translation; MitochondrialChromosomal Location of Human Ortholog: 11q13Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrial ribosomeMolecular Function: protein binding; structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011] |
| UniProt Code: | Q13405 |
| NCBI GenInfo Identifier: | 6093524 |
| NCBI Gene ID: | 740 |
| NCBI Accession: | Q13405.1 |
| UniProt Secondary Accession: | Q13405,B2R4G6 |
| UniProt Related Accession: | Q13405 |
| Molecular Weight: | 19,198 Da |
| NCBI Full Name: | 39S ribosomal protein L49, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L49 |
| NCBI Official Symbol: | MRPL49Â Â |
| NCBI Official Synonym Symbols: | NOF; NOF1; L49mt; C11orf4; MRP-L49Â Â |
| NCBI Protein Information: | 39S ribosomal protein L49, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L49, mitochondrial |
| UniProt Synonym Protein Names: | Neighbor of FAU; NOF; Protein NOF1 |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL49Â Â |
| UniProt Entry Name: | RM49_HUMAN |
