The MRPL4 Antibody (PAC01098) is a vital tool for researchers studying mitochondrial ribosomal protein L4 (MRPL4), a component of the large subunit of the mitochondrial ribosome. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blotting and other research applications.MRPL4 plays a crucial role in protein synthesis within the mitochondria, making it essential for cellular energy production and overall mitochondrial function. Dysregulation of MRPL4 has been linked to various human diseases, including cancer and metabolic disorders, highlighting the importance of studying this protein in a research setting.
By utilizing the MRPL4 Antibody, researchers can effectively detect and analyze MRPL4 expression in different cell types and experimental conditions, providing valuable insights into its function and potential therapeutic implications. This antibody is a valuable tool for studies focusing on mitochondrial biology, cell metabolism, and disease mechanisms, offering a deeper understanding of MRPL4's role in human health and disease.
Antibody Name:
MRPL4 Antibody
Antibody SKU:
PACO01098
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human MRP-L4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL4; CDABP0091; CGI-28; 39S ribosomal protein L4; mitochondrial; L4mt; MRP-L4
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]
