The MRPL33 Polyclonal Antibody (PACO28350) is an essential tool for researchers studying the mitochondrial ribosomal protein L33 (MRPL33). This antibody, generated in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blotting.MRPL33 is a crucial component of the mitochondrial ribosome, where it plays a vital role in protein synthesis within the mitochondria. Research on MRPL33 is essential for understanding mitochondrial function and its implications in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions.
By using the MRPL33 Polyclonal Antibody, researchers can detect and analyze MRPL33 protein levels in different cell types, aiding in their study of mitochondrial protein synthesis and function. This antibody is a valuable tool for investigations into mitochondrial biology and its role in human health and disease.
Antibody Name:
MRPL33 Antibody (PACO28350)
Antibody SKU:
PACO28350
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human 39S ribosomal protein L33, mitochondrial protein (1-65AA)
39S ribosomal protein L33, mitochondrial (L33mt) (MRP-L33) (Mitochondrial large ribosomal subunit protein bL33m), MRPL33, C2orf1
UniProt Protein Function:
MRPL33: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 2p21Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosome
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
