MRPL21 Antibody (PACO37426)
- SKU:
- PACO37426
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
MRPL21 Antibody (PACO37426)
The MRPL21 Antibody (PAC037426) is a valuable tool for researchers studying mitochondrial ribosomal proteins and their role in cellular function. This polyclonal antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in various applications, including Western blot analysis.MRPL21 is a mitochondrial ribosomal protein involved in the translation of mitochondrial DNA and plays a crucial role in protein synthesis within the mitochondria. Dysfunction of MRPL21 has been associated with various diseases, including cancer and mitochondrial disorders.
By using the MRPL21 Antibody, researchers can detect and analyze the expression of MRPL21 in different cell types, providing insights into its function and potential therapeutic applications.This antibody is a valuable tool for studies in mitochondrial biology, cancer research, and mitochondrial diseases. By targeting MRPL21, researchers can further understand the mechanisms underlying these conditions and develop targeted therapies to address them.
| Antibody Name: | MRPL21 Antibody (PACO37426) |
| Antibody SKU: | PACO37426 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human 39S ribosomal protein L21, mitochondrial protein (40-205AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO37426 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO37426 at dilution of 1:100. |
| Background: | mitochondrial inner membrane, mitochondrial large ribosomal subunit, poly(A) RNA binding, structural constituent of ribosome, mitochondrial translation, mitochondrial translational elongation, mitochondrial translational initiation, mitochondrial translational termination, organelle organization |
| Synonyms: | 39S ribosomal protein L21, mitochondrial (L21mt) (MRP-L21) (Mitochondrial large ribosomal subunit protein bL21m), MRPL21 |
| UniProt Protein Function: | MRPL21: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]Protein type: Ribosomal; MitochondrialChromosomal Location of Human Ortholog: 11q13.3Cellular Component: mitochondrial inner membrane; ribosomeMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z2W9 |
| NCBI GenInfo Identifier: | 31652228 |
| NCBI Gene ID: | 219927 |
| NCBI Accession: | NP_852616.1 |
| UniProt Secondary Accession: | Q7Z2W9,A6NKU0, C9JPR2 |
| UniProt Related Accession: | Q7Z2W9 |
| Molecular Weight: | 13,746 Da |
| NCBI Full Name: | 39S ribosomal protein L21, mitochondrial isoform a |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L21 |
| NCBI Official Symbol: | MRPL21Â Â |
| NCBI Official Synonym Symbols: | L21mt; MRP-L21Â Â |
| NCBI Protein Information: | 39S ribosomal protein L21, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L21, mitochondrial |
| UniProt Synonym Protein Names: | |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL21Â Â |
| UniProt Entry Name: | RM21_HUMAN |
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