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GenieFluor 488 Anti-Mouse CD8a Antibody [53-6.7] (AGEL0385)

SKU:
AGEL0385
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
53.6.7
Conjugation:
AF 488
Applications:
FC
€109 - €249
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD8a Antibody [53-6.7]

The Mouse CD8a Monoclonal Antibody (Alexa Fluor 488 Conjugated, 53-6.7) is a cutting-edge tool for researchers studying CD8a, a critical cell surface marker involved in immune responses and T cell function. This monoclonal antibody, specifically engineered for mouse samples, provides exceptional sensitivity and specificity in various experimental applications, including flow cytometry and immunofluorescence.Known for its role in the immune system, CD8a is essential for the identification and activation of cytotoxic T cells, which play a crucial part in immune surveillance and defense against pathogens and cancer cells. By targeting CD8a, researchers can investigate the distribution and function of CD8a-positive cells in different tissues and disease states, advancing our understanding of immune responses and potential therapeutic strategies.

This Alexa Fluor 488-conjugated antibody, clone 53-6.7, offers reliable detection and visualization of CD8a expression in mouse samples, enabling precise analysis and characterization of T cell populations. Its compatibility with various research techniques makes it an invaluable tool for immunologists, oncologists, and researchers exploring the intricate mechanisms of immune regulation and T cell-mediated immunity. Unlock the potential of your research with the Mouse CD8a Monoclonal Antibody (Alexa Fluor 488 Conjugated, 53-6.7) for unparalleled insights into CD8a biology and function.

Product Title:GenieFluor 488 Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL0385
Size:50 Tests, 100 Tests, 200 Tests
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

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