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PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL1644)

SKU:
AGEL1644
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
10F.9G2
Conjugation:
PE/Cy5.5
€199
Frequently bought together:

Description

PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The Mouse CD274 (PD-L1) Monoclonal Antibody PE-Cyanine5.5 Conjugated (10F.9G2) is a powerful tool for researchers studying the programmed death ligand 1 (PD-L1) protein in mice. PD-L1 is a key immune checkpoint molecule that plays a crucial role in regulating the immune response and is a target of interest in cancer immunotherapy. This monoclonal antibody, conjugated with PE-Cyanine5.5 for fluorescence detection, specifically binds to the PD-L1 protein, allowing for the accurate identification and analysis of PD-L1 expression in various cell types and tissues.PD-L1 is known for its role in suppressing the activity of T cells and promoting immune evasion by tumor cells.

Understanding the expression and regulation of PD-L1 is essential for developing effective immunotherapies targeting the PD-L1/PD-1 pathway in cancer treatment. This antibody is highly specific and reliable, making it suitable for use in flow cytometry and other experimental techniques to investigate the function and role of PD-L1 in cancer biology and immune response modulation.With its validated performance and specificity, the Mouse CD274 (PD-L1) Monoclonal Antibody PE-Cyanine5.5 Conjugated (10F.9G2) (AGEL1644) is a valuable asset for research applications focusing on immune checkpoint inhibition, tumor immunology, and the development of novel cancer therapies.

Antibody Name:Mouse CD274/PD-L1 Monoclonal Antibody (PE/Cyanine5.5 Conjugated)
Antibody Code:AGEL1644
Size:50µg
Clone:10F.9G2
Synonyms:B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Host Species:Rat
Species Reactivity:Mouse
Applications:FC
Concentration:1mg/mL
Isotype:IgG2a,k
Conjugation:PE/Cyanine5.5
Applications:FC
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300, 1% BSA
Storage:Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Gene ID:60533
Uniprot:Q9EP73
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
Mouse CD19 Monoclonal Antibody (FITC Conjugated)C57BL/6 murine splenocytes are stained with Anti-Mouse PD-L1 Monoclonal Antibody(PE/Cyanine5.5 Conjugated)[Used at ?g/106 cells dilution](filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.

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