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PE Anti-Mouse CD272 Antibody [PK18.6] (AGEL0755)

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SKU AGEL0755
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
€82 - €200
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Description

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PE Anti-Mouse CD272 Antibody [PK18.6]

The PE-conjugated Mouse CD272 Monoclonal Antibody (PK18-6) is a cutting-edge tool designed for researchers studying CD272, an important immune-related molecule involved in the regulation of immune responses. This monoclonal antibody, specifically developed for use with mouse samples, offers high reactivity and precision in detecting CD272 protein expression. Validated for applications such as flow cytometry, this antibody provides researchers with a reliable means of identifying and analyzing CD272 in various cell types.CD272, also known as B- and T-lymphocyte attenuator (BTLA), is a key immune checkpoint receptor that plays a crucial role in modulating immune responses.

By inhibiting immune cell activation, CD272 contributes to the regulation of immune tolerance and autoimmunity. Its significance in immune regulation makes it a promising target for research in fields such as immunology and cancer biology. Understanding the function of CD272 is essential for developing novel therapeutic strategies aimed at manipulating immune responses and potentially treating immune-related disorders such as cancer and autoimmune diseases.

Product Title:PE Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL0755
Size:50 Tests, 100 Tests, 200 Tests
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:PE Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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