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PE Anti-Mouse CD206 Antibody [C068C2] (AGEL1652)

SKU:
AGEL1652
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€219 - €449
Frequently bought together:

Description

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PE Anti-Mouse CD206 Antibody [C068C2]

The Mouse CD206 Monoclonal Antibody (PE Conjugated) (C068C2-AGEL1652) is a specialized antibody designed for research applications involving CD206, a cell surface receptor known for its role in immune regulation and antigen presentation. This monoclonal antibody, conjugated with PE for easy detection, is specifically targeted for use with mouse samples, offering high reactivity and specificity.CD206, also referred to as the mannose receptor, is a key player in the immune system, particularly in antigen uptake and processing. Its involvement in modulating immune responses and antigen presentation makes it a crucial target for studies in immunology, infectious diseases, and host-pathogen interactions.

By binding specifically to CD206, this monoclonal antibody enables precise detection and analysis in various experimental settings, providing valuable insights into the functions of this receptor in different cell types.Researchers exploring topics such as macrophage biology, host immunity, and infectious disease mechanisms will find the Mouse CD206 Monoclonal Antibody (PE Conjugated) (C068C2-AGEL1652) to be a valuable tool for their investigations. Its reliability, sensitivity, and specificity make it well-suited for applications such as flow cytometry, immunofluorescence, and cell sorting, facilitating detailed studies into the intricate roles of CD206 in the immune response.

Product Title:PE Anti-Mouse CD206 Antibody [C068C2]
SKU:AGEL1652
Size:50 Tests, 100 Tests, 200 Tests
Clone No:C068C2
Synonyms:MMR;MR;MRC1;macrophage mannose receptor;mannose receptor ;
Host Species:Rat
Reactivity:Mouse
Application:FCM;ICFCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q61830
Gene ID:17533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

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