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PE/Cyanine5.5 Anti-Mouse CD162 Antibody [4RA10] (AGEL0852)

SKU:
AGEL0852
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€199 - €459
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Mouse CD162 Antibody [4RA10]

The Mouse CD162 Monoclonal Antibody (PE-Cyanine5.5 Conjugated) is a cutting-edge tool for researchers studying cell adhesion molecules and immune responses in the context of inflammation and immune regulation. This monoclonal antibody specifically targets CD162, a cell surface molecule involved in cell adhesion processes and immune cell interactions.With a PE-Cyanine5.5 conjugation, this antibody offers high sensitivity and specificity for detecting CD162 in flow cytometry and fluorescence microscopy applications. It enables researchers to analyze CD162 expression levels in different cell populations, providing valuable insights into immune cell functions and interactions.CD162, also known as PSGL-1 (P-selectin glycoprotein ligand-1), is a key player in leukocyte trafficking and adhesion to endothelial cells during inflammatory responses.

Understanding the role of CD162 in immune cell migration and activation is essential for unraveling the mechanisms underlying inflammatory diseases, such as atherosclerosis and autoimmune conditions.By using the Mouse CD162 Monoclonal Antibody (PE-Cyanine5.5 Conjugated), researchers can delve deeper into the complex interplay between immune cells and vascular endothelium, paving the way for innovative therapeutic strategies targeting CD162-mediated immune responses. Upgrade your research capabilities with this advanced antibody and unlock new discoveries in the field of immunology and inflammation research.

Product Title:PE/Cyanine5.5 Anti-Mouse CD162 Antibody [4RA10]
SKU:AGEL0852
Size:25µg, 100µg
Clone No:4RA10
Synonyms:P-selectin glycoprotein ligand 1;Selplg;PSGL-1;Selectin P ligand;CD162;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:PE/Cyanine5.5 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62170
Gene ID:20345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.

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