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PE Anti-Mouse CD150 Antibody [TC15-12F12.2] (AGEL1883)

SKU:
AGEL1883
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€169 - €459
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Title:PE Anti-Mouse CD150 Antibody [TC15-12F12.2]
SKU:AGEL1883
Size:25µg, 100µg
Clone No:TC15-12F12.2
Synonyms:Slam;Slamf1;CD 150;Signaling lymphocytic activation molecule;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, λ
Isotype Control:PE Rat IgG2a, λ Isotype Control[B39-4]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q9QUM4
Gene ID:27218
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.

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