The MMP9 Polyclonal Antibody (CAB2095) is a valuable tool for researchers studying Matrix Metalloproteinase 9 (MMP9), an enzyme involved in extracellular matrix remodeling and tissue repair processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to MMP9, this antibody allows for the detection and analysis of MMP9 expression in various cell types, making it an essential component of studies focused on cancer, inflammation, and tissue remodeling.
MMP9 is known for its role in promoting tumor growth, invasion, and metastasis by degrading extracellular matrix components. Its overexpression is associated with poor prognosis in cancer patients, making MMP9 an attractive target for therapeutic interventions. By investigating the function and regulation of MMP9 using this antibody, researchers can gain insights into the mechanisms underlying cancer progression and identify potential targets for anti-cancer therapies.
Product Name:
[KO Validated] MMP9 Rabbit Polyclonal Antibody
SKU:
CAB2095
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 538-707 of human MMP9 (NP_004985.2).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Purification Method:
Affinity purification
Gene ID:
4318
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse spleen using MMP9 Rabbit pAb(CAB2095) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:30s.
