The MMP13 Monoclonal Antibody is a highly specific tool for research involving MMP13, a key enzyme involved in extracellular matrix degradation and tissue remodeling. This antibody, produced using a monoclonal antibody technology, is designed to target MMP13 with high sensitivity and specificity in a variety of biological samples. MMP13, also known as collagenase 3, is a critical player in processes such as tissue repair, wound healing, and cell migration. Dysregulation of MMP13 has been implicated in various diseases, including arthritis, cancer metastasis, and cardiovascular diseases.
Understanding the expression and activity of MMP13 is essential for unraveling its role in these pathological conditions and identifying potential therapeutic targets.This MMP13 Monoclonal Antibody is suitable for use in techniques such as Western blot, immunohistochemistry, and immunofluorescence, providing researchers with a versatile tool for studying MMP13 in different experimental settings. With its high specificity and sensitivity, this antibody is a valuable asset for investigations into the biology and pathology of MMP13 in various research fields.
Product Name:
MMP13 Monoclonal Antibody
SKU:
CAB22334
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 104-272 of human MMP13 (NP_002418.1).
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11.
Purification Method:
Affinity purification
Gene ID:
4322
Clone Number:
ARC51250
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunofluorescence analysis of MCF7 cells using MMP13 Rabbit mAb (CAB22334) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
