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MMP1 Polyclonal Antibody (CAB24437)

SKU:
CAB24437
$311
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MMP1 Polyclonal Antibody
SKU:CAB24437
Size:100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 369-469 of human MMP1 (NP_002412.1).
Sequence:FPRT VKHI DAAL SEEN TGKT YFFV ANKY WRYD EYKR SMDP GYPK MIAH DFPG IGHK VDAV FMKD GFFY FFHG TRQY KFDP KTKR ILTL QKAN SWFN CRKN
Tested Applications:WB
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:CLG; CLGN; MMP1
Positive Sample:BeWo
Conjugate:Unconjugated
Cellular Localization:Secreted, extracellular matrix, extracellular space.
Calculated MW:54kDa
Observed MW:57kDa

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Purification Method:Affinity purification
Gene ID:4312
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from BeWo cells, using MMP1 Rabbit pAb (CAB24437) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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