MLH3 Rabbit Polyclonal Antibody (CAB7796)
- SKU:
- CAB7796
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MLH3 Rabbit Polyclonal Antibody |
SKU: | CAB7796 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1190-1389 of human MLH3 (NP_055196.2). |
Sequence: | QVLQ QVDN KFIA CLMS TKTE ENGE ADSY EKQQ AQGS GRKK LLSS TLIP PLEI TVTE EQRR LLWC YHKN LEDL GLEF VFPD TSDS LVLV GKVP LCFV EREA NELR RGRS TVTK SIVE EFIR EQLE LLQT TGGI QGTL PLTV QKVL ASQA CHGA IKFN DGLS LQES CRLI EALS SCQL PFQC AHGR PSML PLAD IDHL EQEK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HNPCC7; MLH3 |
Positive Sample: | HCT116 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 164kDa |
Observed MW: | 164kDa |
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Purification Method: | Affinity purification |
Gene ID: | 27030 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |