The MKKS Polyclonal Antibody (CAB15336) is a valuable tool for researchers studying the MKKS protein, which is involved in ciliogenesis and ciliary function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the MKKS protein, this antibody allows for precise detection and analysis in various cell types, making it an ideal choice for investigations in the fields of cell biology and genetics.MKKS is a crucial player in the biogenesis and maintenance of cilia, which are hair-like structures on the surface of cells that play essential roles in cell signaling, sensory perception, and motility.
Mutations in the MKKS gene have been linked to a group of genetic disorders known as ciliopathies, which can lead to a range of developmental abnormalities and disease conditions. Consequently, studying the function and regulation of MKKS is essential for advancing our understanding of ciliary biology and uncovering potential therapeutic targets for ciliopathy-related disorders. Overall, the MKKS Polyclonal Antibody offers researchers a reliable tool to investigate the role of the MKKS protein in various cellular processes and to further explore its implications in ciliary-related diseases.
Product Name:
MKKS Rabbit Polyclonal Antibody
SKU:
CAB15336
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 221-570 of human MKKS (NP_740754.1).
This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8195
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells, using MKKS Rabbit pAb (CAB15336) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
