The MGLL Polyclonal Antibody (PAC053698) is a valuable tool for researchers studying the role of MGLL, also known as monoacylglycerol lipase, in various cellular processes. This antibody, generated in rabbits, exhibits high reactivity with samples from multiple species, including human, mouse, and rat, making it a versatile tool for a wide range of experimental models.MGLL is a key enzyme involved in the metabolism of endocannabinoids, specifically hydrolyzing 2-arachidonoylglycerol (2-AG) to regulate cannabinoid receptor signaling pathways. Dysregulation of MGLL has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions, highlighting its importance as a therapeutic target.
By utilizing the MGLL Polyclonal Antibody, researchers can detect and quantify MGLL protein levels in different tissues and cell types using Western blotting, immunofluorescence, and immunohistochemistry techniques. This antibody provides a reliable tool for investigating the function of MGLL in lipid metabolism, signaling pathways, and disease progression, ultimately aiding in the development of targeted therapies for MGLL-related disorders.
Antibody Name:
Mgll Antibody (PACO53698)
Antibody SKU:
PACO53698
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Rat, Mouse
Immunogen:
Recombinant Rat Monoglyceride lipase protein (1-303AA)
Western Blot. Positive WB detected in: Rat lung tissue, Mouse brain tissue. All lanes: Mgll antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 34 kDa. Observed band size: 34 kDa.
Background:
Converts monoacylglycerides to free fatty acid, and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acid, that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
UniProt Protein Details:
NCBI Summary:
serine hydrolase that converts monoglycerides to fatty acid and glycerol; may play a role in retrograde signaling at central synapses and other forms of short-range neuronal communication [RGD, Feb 2006]
