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MDM2 Monoclonal Antibody (CAB23387)

SKU:
CAB23387
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
IHC
€139 - €529
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MDM2 Monoclonal Antibody
SKU:CAB23387
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 101-200 of human MDM2 (NP_001354919.1).
Sequence:TMIY RNLV VVNQ QESS DSGT SVSE NRCH LEGG SDQK DLVQ ELQE EKPS SSHL VSRP STSS RRRA ISET EENS DELS GERQ RKRH KSDS ISLS FDES LALC
Tested Applications:IHC-P ELISA
Recommended Dilution:IHC-P,1:50 - 1:200
Synonyms:HDMX; LSKB; hdm2; ACTFS; MDM2
Positive Sample:U2OS+Nutlin 3a
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus, nucleolus, nucleoplasm.
Calculated MW:55kDa
Observed MW:Refer to figures

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Purification Method:Affinity purification
Gene ID:4193
Clone Number:ARC60294
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded human lung squamous carcinoma tissue using MDM2 Rabbit mAb (CAB23387) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

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