The MCUB Polyclonal Antibody (PAC041186) is a valuable tool for research involving MCUB, a mitochondrial inner membrane protein implicated in calcium uptake regulation. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding to the MCUB protein, this antibody allows for the detection and analysis of MCUB in various cell types, making it well-suited for studies in mitochondrial biology and calcium signaling.MCUB plays a crucial role in maintaining mitochondrial calcium homeostasis, which is essential for various cellular processes, including energy production and cell death regulation.
Dysregulation of MCUB has been linked to mitochondrial dysfunction and cellular stress, highlighting its importance in cellular physiology and disease development. Research into MCUB function is key to understanding the role of mitochondrial calcium dynamics in health and disease, and may lead to the development of novel therapeutic strategies targeting mitochondrial function.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO41186 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO41186 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
