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JNK2 Polyclonal Antibody (CAB1251)

SKU:
CAB1251
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:JNK2 Polyclonal Antibody
SKU:CAB1251
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-424 of human JNK2 (NP_002743.3).
Sequence:MSDS KCDS QFYS VQVA DSTF TVLK RYQQ LKPI GSGA QGIV CAAF DTVL GINV AVKK LSRP FQNQ THAK RAYR ELVL LKCV NHKN IISL LNVF TPQK TLEE FQDV YLVM ELMD ANLC QVIH MELD HERM SYLL YQML CGIK HLHS AGII HRDL KPSN IVVK SDCT LKIL DFGL ARTA CTNF MMTP YVVT RYYR APEV ILGM GYKE NVDI WSVG CIMG ELVK GCVI FQGT DHID QWNK VIEQ LGTP SAEF MKKL QPTV RNYV ENRP KYPG IKFE ELFP DWIF PSES ERDK IKTS QARD LLSK MLVI DPDK RISV DEAL RHPY ITVW YDPA EAEA PPPQ IYDA QLEE REHA IEEW KELI YKEV MDWE ERSK NGVV KDQP SDAA VSSN ATPS QSSS INDI SSMS TEQT LASD TDSS LDAS TGPL EGCR
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA; K2
Positive Sample:MCF-7,DU145,THP-1,Mouse liver
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:48kDa
Observed MW:54kDa

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Purification Method:Affinity purification
Gene ID:5601
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using JNK2 antibody (CAB1251) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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