The MAP2 Polyclonal Antibody (PAC018440) is a valuable tool for researchers studying Microtubule-associated protein 2 (MAP2), a key protein involved in the development and maintenance of neuronal cells. This antibody is produced in rabbits and has a high reactivity with human samples, making it an ideal choice for experiments such as Western blotting. By binding specifically to the MAP2 protein, this antibody allows for the precise detection and analysis of MAP2 in various cell types, providing insight into its functions in neurobiology and neurodegenerative diseases.MAP2 is essential for the stability and organization of microtubules in neuronal cells, playing a crucial role in processes such as neuronal development, synaptic plasticity, and neuronal plasticity.
Dysregulation of MAP2 has been implicated in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, making it a promising target for therapeutic interventions. By using the MAP2 Polyclonal Antibody, researchers can further investigate the roles of MAP2 in normal brain function and neurological disorders, leading to potential advancements in treatment strategies for these conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18440(Map2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8+10+12%SDS-PAGE, Lysate: 50 μg, Lane: Human lymphoma tissue, Primary antibody: PACO18440(Map2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18440(Map2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. It contains 3 Tau/MAP repeats. Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly.
Synonyms:
microtubule-associated protein 2
UniProt Protein Function:
MAP2: a member of the microtubule-associated protein (MAP) family. Its exact function is unknown but MAPs appear to stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Expressed at high levels in neural tissue and the prostate. Four alternatively spliced transcript variants have been reported.Protein type: Motility/polarity/chemotaxis; CytoskeletalCellular Component: microtubule; neuron projection; smooth endoplasmic reticulum; protein complex; rough endoplasmic reticulum; postsynaptic density; dendrite; microtubule associated complex; cytoskeleton; cell soma; cytoplasm; nucleolus; intracellular; dendritic shaftMolecular Function: tubulin binding; calmodulin binding; protein binding; microtubule binding; cytoskeletal regulatory protein bindingBiological Process: axonogenesis; dendrite development; microtubule bundle formation
