The MAP1LC3B2 Polyclonal Antibody (PAC047530) is a valuable tool for researchers studying autophagy and related processes. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MAP1LC3B2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in the fields of cell biology, oncology, and neurodegenerative diseases.
MAP1LC3B2, a member of the MAP1LC3 family, plays a key role in the autophagy pathway by facilitating the formation of autophagosomes. Dysregulation of autophagy has been linked to a number of diseases, including cancer, neurodegenerative disorders, and infectious diseases. By understanding the function of MAP1LC3B2, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Antibody Name:
MAP1LC3B2 Antibody (PACO47530)
Antibody SKU:
PACO47530
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Microtubule-associated proteins 1A/1B light chain 3 β 2 protein (1-47AA)
Immunofluorescent analysis of Hela cells using PACO47530 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).
