The MAGEA8 Monoclonal Antibody (PAC016644) is a powerful tool for research involving MAGEA8, a member of the MAGE family of cancer-testis antigens. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it an ideal choice for studies in oncology and immunotherapy. MAGEA8 is known to be overexpressed in various cancer types, including melanoma, lung cancer, and breast cancer, and its role in promoting tumor growth and metastasis has been well-documented. The MAGEA8 Monoclonal Antibody binds specifically to MAGEA8 protein, enabling researchers to detect and analyze its expression in tumor cells and patient samples.
By studying the expression and function of MAGEA8, researchers can gain valuable insights into the mechanisms underlying cancer progression and identify potential targets for therapeutic intervention. The MAGEA8 Monoclonal Antibody is a valuable tool for advancing our understanding of cancer biology and developing novel treatment strategies for patients with MAGEA8-positive tumors.
Antibody Name:
MAGEA8 Antibody (PACO16644)
Antibody SKU:
PACO16644
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Fusion protein of human MAGEA8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A375 cells, human lung cancer tissue, Primary antibody: PACO16644(MAGEA8 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
Background:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms:
melanoma antigen family A, 8
UniProt Protein Function:
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]
