The MacroH2A.1 Rabbit Monoclonal Antibody (CAB9059) is a valuable tool for researchers studying the histone variant MacroH2A.1, which plays a key role in chromatin structure and gene regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting MacroH2A.1 in human samples, making it an ideal choice for use in Western blot applications.MacroH2A.1 is a histone variant that has been implicated in a variety of biological processes, including transcriptional regulation, DNA repair, and cellular differentiation.
Dysregulation of MacroH2A.1 has been linked to various diseases, such as cancer and developmental disorders, making it a promising target for further investigation.By utilizing the MacroH2A.1 Rabbit Monoclonal Antibody, researchers can gain valuable insights into the functions of MacroH2A.1 in different cellular contexts, advancing our understanding of chromatin biology and its implications in human health and disease. This antibody is a valuable tool for studies in epigenetics, cancer research, and beyond.
Product Name:
macroH2A.1 Rabbit Monoclonal Antibody
SKU:
CAB9059
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human macroH2A.1 (O75367).
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
9555
Clone Number:
ARC1396
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using macroH2A.1 Rabbit mAb (CAB9059) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
