The MACROD1 Polyclonal Antibody (PAC040286) is a valuable tool for researchers studying the MACROD1 protein, a critical player in DNA damage repair and genome stability. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MACROD1 protein, this antibody enables the detection and analysis of MACROD1 in various cell types, making it an essential reagent for studies in molecular biology and cancer research.MACROD1, also known as a macrodomain-containing protein, plays a crucial role in maintaining genomic integrity by facilitating the repair of DNA damage and preventing the accumulation of mutations.
Dysregulation of MACROD1 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting the importance of understanding its function and regulation. The MACROD1 Polyclonal Antibody is a valuable tool for researchers seeking to deepen their understanding of MACROD1's role in disease development and progression.
Antibody Name:
MACROD1 Antibody (PACO40286)
Antibody SKU:
PACO40286
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 protein (83-325AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO40286 at dilution of 1:100.
Background:
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
