The MACF1 Antibody (PAC013693) is a polyclonal antibody developed for research involving MACF1, a key protein involved in cell migration and cytoskeletal organization. This antibody, generated against MACF1 in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to MACF1, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it an excellent tool for studies in cell biology and cancer research.MACF1, also known as microtubule actin crosslinking factor 1, plays a crucial role in mediating the interactions between microtubules and actin filaments, essential for cell shape and movement.
Dysregulation of MACF1 has been implicated in various cellular processes and diseases, including cancer metastasis and neurological disorders. By understanding the function and regulation of MACF1, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
