The LYPLA1 Polyclonal Antibody (PAC028090) is a valuable tool for research involving LYPLA1, a lysophospholipase enzyme that plays a crucial role in lipid metabolism and signaling pathways. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By binding to the LYPLA1 protein, researchers can accurately detect and analyze its expression in various cell types, facilitating studies in metabolic disorders, cancer, and neurodegenerative diseases.
LYPLA1 is known to be involved in the breakdown of lysophospholipids, which are important components of cell membranes and signaling molecules. Dysregulation of LYPLA1 activity has been implicated in conditions such as obesity, diabetes, and neurological disorders. As such, the LYPLA1 Polyclonal Antibody is a valuable tool for investigating the role of this enzyme in disease pathogenesis and for developing targeted therapies that modulate lipid metabolism.
Antibody Name:
Lypla1 Antibody (PACO28090)
Antibody SKU:
PACO28090
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Acyl-protein thioesterase 1 protein (1-230AA)
Immunofluorescent analysis of Hela cells using PACO28090 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Hydrolyzes fatty acid, from S-acylated cysteine residues in proteins such as trimeric G α proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.
LYPLA1: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity. Belongs to the AB hydrolase 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.2.-; Lipid Metabolism - glycerophospholipid; Mitochondrial; PhospholipaseChromosomal Location of Human Ortholog: 1|1 A1Cellular Component: cytosol; mitochondrionMolecular Function: lipase activity; lysophospholipase activity; palmitoyl-(protein) hydrolase activityBiological Process: negative regulation of Golgi to plasma membrane protein transport; protein depalmitoylation
