The LRTM1 Polyclonal Antibody (PAC041954) is a valuable tool for researchers studying LRTM1, a protein involved in synaptic plasticity and neurodevelopment. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By targeting the LRTM1 protein, this antibody allows for the detection and analysis of LRTM1 in various cell types, making it an essential component for investigations in neuroscience and neurobiology.LRTM1 is known to play a crucial role in the regulation of excitatory synapse development and function, making it a key player in processes such as learning and memory formation.
Dysregulation of LRTM1 has been implicated in various neurological disorders, including autism and schizophrenia, highlighting the importance of studying this protein in a research setting. By utilizing the LRTM1 Polyclonal Antibody, researchers can further our understanding of the role of LRTM1 in normal brain function and pathological conditions, potentially leading to the development of novel therapeutic strategies.
Western blot. All lanes: LRTM1 antibody at 0.4µg/ml + K562 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 39, 30 kDa. Observed band size: 39 kDa.
Immunofluorescence staining of Hela cells with PACO41954 at 1:13, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO41954 at dilution of 1:100.
Synonyms:
Leucine-rich repeat and transmembrane domain-containing protein 1, LRTM1
UniProt Protein Function:
LRTM1: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3p14.3Cellular Component: cytoplasmMolecular Function: protein kinase inhibitor activityBiological Process: cytokine and chemokine mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity
