The LRP6 Monoclonal Antibody is a valuable tool for researchers studying the LRP6 protein, a key player in the Wnt signaling pathway. This antibody, developed using monoclonal technology, is highly specific to LRP6 and is compatible with a variety of research applications, including Western blotting and immunofluorescence.LRP6 is crucial for the activation of Wnt signaling, a pathway involved in many cellular processes such as cell proliferation, differentiation, and migration. Dysregulation of the Wnt pathway, often caused by mutations in LRP6, has been implicated in various diseases including cancer, osteoporosis, and neurodevelopmental disorders.
By targeting LRP6 with this monoclonal antibody, researchers can investigate its role in Wnt signaling and its potential as a therapeutic target for diseases associated with pathway dysregulation. This antibody is a valuable tool for advancing our understanding of LRP6 function and its implications in health and disease.
Product Name:
LRP6 Monoclonal Antibody
SKU:
CAB22661
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human LRP6 (NP_002327.2).
Endoplasmic reticulum, Membrane, Single-pass type I membrane protein.
Calculated MW:
180kDa
Observed MW:
180kDa
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Purification Method:
Affinity purification
Gene ID:
4040
Clone Number:
ARC54062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis extracts from HeLa cells, using LRP6 antibody (CAB22661) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
