The LCE1B Polyclonal Antibody (PACO47502) is a valuable tool for researchers studying LCE1B, a member of the late cornified envelope (LCE) gene cluster that plays a role in skin barrier function and protection. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in a variety of research applications, including Western blotting and immunohistochemistry.LCE1B is involved in the formation of the cornified cell envelope, a crucial component of the skin barrier that helps protect against external threats such as pathogens and environmental stressors.
Dysregulation of LCE1B expression has been associated with skin disorders, making it an important target for research in dermatology and skin biology.By using the LCE1B Polyclonal Antibody, researchers can accurately detect and analyze LCE1B protein levels in different cell types and tissues, advancing our understanding of its function in skin health and disease. This antibody is a valuable tool for investigating the role of LCE1B in skin barrier function and exploring potential therapeutic strategies for skin conditions related to barrier dysfunction.
Immunohistochemistry of paraffin-embedded human skin tissue using PACO47502 at dilution of 1:100.
Immunofluorescent analysis of A375 cells using PACO47502 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Precursors of the cornified envelope of the stratum corneum.
Synonyms:
Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A), LCE1B, LEP2 SPRL2A
UniProt Protein Function:
LCE1B: Precursors of the cornified envelope of the stratum corneum. Belongs to the LCE family. Induced by UVBChromosomal Location of Human Ortholog: 1q21.3Biological Process: keratinization
late cornified envelope protein 1B; late envelope protein 2; small proline rich-like (epidermal differentiation complex) 2A; small proline-rich-like epidermal differentiation complex protein 2A
UniProt Protein Name:
Late cornified envelope protein 1B
UniProt Synonym Protein Names:
Late envelope protein 2; Small proline-rich-like epidermal differentiation complex protein 2A
