The Lamin B2 Polyclonal Antibody (CAB6483) is a valuable tool for researchers studying the nuclear protein Lamin B2. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Lamin B2 protein, this antibody enables researchers to detect and analyze Lamin B2 in various cell types, making it ideal for studies in cell biology, molecular biology, and cancer research. Lamin B2 is an essential component of the nuclear lamina, providing structural support to the nucleus and playing a key role in nuclear organization and stability.
Dysregulation of Lamin B2 has been implicated in various diseases, including cancer, muscular dystrophy, and premature aging disorders. By studying Lamin B2 using this polyclonal antibody, researchers can gain valuable insights into the role of this protein in health and disease, ultimately leading to the development of novel therapeutic strategies.
Product Name:
Lamin B2 Rabbit Polyclonal Antibody
SKU:
CAB6483
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 341-620 of human Lamin B2 (NP_116126.3).
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy.
Purification Method:
Affinity purification
Gene ID:
84823
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Lamin B2 Rabbit pAb (CAB6483) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
