The Laforin Polyclonal Antibody (CAB7007) is a valuable tool for researchers studying Lafora disease, a rare inherited neurodegenerative disorder characterized by the accumulation of insoluble glycogen-like particles in cells. Laforin, the protein targeted by this antibody, is a key player in glycogen metabolism and abnormalities in its function have been linked to the development of Lafora disease.Raised in rabbits, this antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to Laforin, researchers can accurately detect and analyze this protein in various cell types, providing insights into its role in glycogen metabolism and its potential implications for disease development.
With its critical involvement in the pathogenesis of Lafora disease, the Laforin Polyclonal Antibody is an essential tool for advancing our understanding of this debilitating disorder. By unraveling the mechanisms underlying Laforin's function, researchers can pave the way for the development of targeted therapies and interventions aimed at ameliorating the symptoms and progression of Lafora disease.
Product Name:
EPM2A Rabbit Polyclonal Antibody
SKU:
CAB7007
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 244-331 of human EPM2A (NP_005661.1).
This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Loss-of-function mutations in this gene have been associated with Lafora disease, a rare, adult-onset recessive neurodegenerative disease, which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of insoluble particles called Lafora bodies, which are derived from glycogen.
Purification Method:
Affinity purification
Gene ID:
7957
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using EPM2A Rabbit pAb (CAB7007) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
