KRT6A/KRT6B/KRT6C Antibody (PACO17700)
- SKU:
- PACO17700
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KRT6A/KRT6B/KRT6C Antibody (PACO17700)
The KRT6A/KRT6B/KRT6C Antibody (PAC017700) is a polyclonal antibody designed for research involving keratin 6 proteins, specifically KRT6A, KRT6B, and KRT6C. These keratins are commonly found in epithelial cells and are important for maintaining skin integrity and providing structural support. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications such as Western blot and immunohistochemistry. By binding to the KRT6A, KRT6B, and KRT6C proteins, researchers can detect and analyze their expression levels in different cell types and tissues, making it a valuable tool for studies in dermatology, cancer research, and cell biology.
Understanding the role of KRT6A, KRT6B, and KRT6C in various physiological and pathological conditions is essential for developing strategies to treat skin disorders, cancers, and other diseases where aberrant expression of keratins may be involved. This antibody provides researchers with a reliable means to investigate the functions of these keratins and their potential implications in human health.
| Antibody Name: | KRT6A/KRT6B/KRT6C Antibody (PACO17700) |
| Antibody SKU: | PACO17700 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human KRT6A/KRT6B/KRT6C |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17700(KRT6A/KRT6B/KRT6C/KRT6B/KRT6C Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO17700(KRT6A/KRT6B/KRT6C Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
| Synonyms: | keratin 6A/keratin 6B/keratin 6C |
| UniProt Protein Function: | K6a: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Associates with K16 and/or -17. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: membrane; keratin filament; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton Biological Process: wound healing; positive regulation of cell proliferation; morphogenesis of an epithelium; cell differentiation Disease: Pachyonychia Congenita 3 |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P02538 |
| NCBI GenInfo Identifier: | 1346344 |
| NCBI Gene ID: | 3853 |
| NCBI Accession: | P02538.3 |
| UniProt Related Accession: | P02538 |
| Molecular Weight: | 60kDa |
| NCBI Full Name: | Keratin, type II cytoskeletal 6A |
| NCBI Synonym Full Names: | keratin 6A |
| NCBI Official Symbol: | KRT6AÂ Â |
| NCBI Official Synonym Symbols: | K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6DÂ Â |
| NCBI Protein Information: | keratin, type II cytoskeletal 6A |
| UniProt Protein Name: | Keratin, type II cytoskeletal 6A |
| UniProt Synonym Protein Names: | Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; K6A; Type-II keratin Kb6; Allergen: Hom s 5 |
| UniProt Gene Name: | KRT6AÂ Â |
| UniProt Entry Name: | K2C6A_HUMAN |
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