The KPNA1 Polyclonal Antibody (CAB1742) is a valuable tool for researchers studying KPNA1, a protein involved in the transport of proteins into the nucleus. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to KPNA1, this antibody allows for the detection and analysis of the protein in various cell types, making it ideal for studies in molecular biology and cancer research.KPNA1, also known as importin alpha-5, plays a crucial role in nucleocytoplasmic transport, enabling the movement of proteins into the nucleus for various cellular processes.
Dysregulation of KPNA1 has been implicated in diseases such as cancer, highlighting its potential as a therapeutic target. Research into KPNA1 can provide valuable insights into the mechanisms of disease development and help identify potential treatment strategies targeting nucleocytoplasmic transport pathways.
Product Name:
KPNA1 Rabbit Polyclonal Antibody
SKU:
CAB1742
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KPNA1 (NP_002255.3).
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3836
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using KPNA1 Rabbit pAb (CAB1742) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
