The KO Validated SUZ12 Polyclonal Antibody (CAB7786) is a valuable tool for researchers studying SUZ12, a key component of the polycomb repressive complex 2 (PRC2) involved in epigenetic regulation. This polyclonal antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting SUZ12 in various biological samples, making it ideal for use in techniques such as Western blotting.SUZ12 is essential for the function of PRC2, which plays a critical role in gene regulation by modifying chromatin structure. Dysregulation of SUZ12 has been implicated in various diseases, including cancer and developmental disorders.
By targeting SUZ12 with this validated antibody, researchers can gain insights into its role in chromatin modification and gene regulation, providing valuable information for understanding disease mechanisms and potential therapeutic targets.Overall, the KO Validated SUZ12 Polyclonal Antibody (CAB7786) is a reliable tool for investigating the function of SUZ12 and its implications in epigenetic regulation and disease pathogenesis. Its high specificity and validation in knockout studies make it a valuable asset for researchers in the fields of molecular biology, genetics, and epigenetics.
Product Name:
[KO Validated] SUZ12 Rabbit Polyclonal Antibody
SKU:
CAB7786
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 470-739 of human SUZ12 (NP_056170.2).
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
CHET9; IMMAS; JJAZ1; 12
Positive Sample:
HeLa,BT-474,MCF-7,293T
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
83kDa
Observed MW:
83kDa
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Purification Method:
Affinity purification
Gene ID:
23512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] SUZ12 Rabbit pAb (CAB7786) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
