[KO Validated] Smad3 Rabbit Monoclonal Antibody (CAB19115)
- SKU:
- CAB19115
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | [KO Validated] Smad3 Rabbit Monoclonal Antibody |
SKU: | CAB19115 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Smad3 (NP_005893.1). |
Sequence: | HHEL RAME LCEF AFNM KKDE VCVN PYHY QRVE TPVL PPVL VPRH TEIP AEFP PLDD YSHS IPEN TNFP AGIE PQSN IPET PPPG YLSE DGET SDHQ MNHS M |
Tested Applications: | WB IHC-P IP ELISA |
Recommended Dilution: | WB,1:2000 - 1:20000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | LDS3; mad3; LDS1C; MADH3; JV15-2; hMAD-3; hSMAD3; HSPC193; HsT17436; d3 |
Positive Sample: | HCT116,A-549,C2C12,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 48kDa |
Observed MW: | 52kDa |
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3.
Purification Method: | Affinity purification |
Gene ID: | 4088 |
Clone Number: | ARC53861 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |